猪链球菌LuxS/AI-2型密度感应系统研究进展

doi:10.11843/j.issn.0366-6964.2018.02.001

Abstract

Abstract:

Quorum sensing (QS) system is a microbial cell-to-cell communication process that can influence the transcriptional expression of multiple genes by one or more signaling molecules to coordinate the population response of multiple bacterial pathogens. It relies on the production and detection of chemical signals called autoinducers to monitor cell density and species complexity in the population. The system includes a variety of types, which LuxS/AI-2 type is one of the hottest types, luxS as a highly conserved gene, involved in the regulation of a variety of gene expression, thereby regulating the growth and virulence of bacteria and other life activities, to adapt to different environments. LuxS protein cleaves S-ribosylhomocysteine to form homocysteine and 4, 5-dihydroxy-2, 3-pentanedione (DPD) which is then spontaneously cyclized to form AI-2. Streptococcus suis (SS) is a major swine pathogen and an emerging zoonotic agent of human meningitis and streptococcal toxic shock-like syndrome. It is of great significance to study the SS LuxS/AI-2 system and uses LuxS/AI-2 system to prevent and treat SS disease. This review focuses on the general mechanism of QS system in SS, the discovery, structure, metabolism, expression and regulation of LuxS/AI-2.

CLC Number:

S852.611

WANG Yu-xin, WANG Yang, YI Li, LU Cheng-ping. LuxS/AI-2 System of Streptococcus suis[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(2): 223-230.

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LuxS/AI-2 System of Streptococcus suis

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